The disease is synonymous with a life of excess, with famous sufferers such as Henry VIII, who was known for his indulgence in food and drink. However, research suggests that gout may be caused by genetics rather than lifestyle.
Researchers at the University of Otago in New Zealand tested the genes of 2.6 million people around the world and found hundreds of markers for the condition in their DNA.
Cases of gout have soared in recent years, increasing by nearly 1000% in the past four years in some parts of England. Symptoms include hot, red, and swollen skin in the affected area and sudden, severe joint pain.
The authors of the study, published in Nature Genetics, hope that the study will reduce some of the stigma surrounding gout. Its lead author, Professor Tony Merriman, said: “Gout is a chronic disease with a genetic basis and is not the patient’s fault. The myth that gout is caused by lifestyle and diet needs to be broken.”
“This widespread myth creates shame for gout sufferers, and may cause some to suffer in silence and not go to the doctor to receive preventive medication that lowers uric acid levels in the blood and prevents pain. It becomes more sexual.
“People believe that while certain dietary factors, such as eating red meat, can trigger gout attacks, the underlying cause may be high uric acid levels, crystals in the joints, and the ability to ‘attack’ the crystals. You need to understand that your immune system is primed. Genetics plays an important role in all these processes. ”
The study identified several genes and pathways that may provide new treatments to prevent gout attacks, and found 377 different genetic loci associated with the disease. Attacks are often treated with anti-inflammatory drugs such as ibuprofen, but steroids can also be used if needed, and new research could ultimately help scientists find better treatments. It is expected.
“We hope that in time, better and more accessible treatments using the new targets we have identified will become available,” Merriman said. It should be more invested in and prioritized in the health care system.”
